Correction: Development of a Mimotope Vaccine Targeting the Staphylococcus aureus Quorum Sensing Pathway
نویسنده
چکیده
[This corrects the article DOI: 10.1371/journal.pone.0111198.].
منابع مشابه
Development of a Mimotope Vaccine Targeting the Staphylococcus aureus Quorum Sensing Pathway
A major hurdle in vaccine development is the difficulty in identifying relevant target epitopes and then presenting them to the immune system in a context that mimics their native conformation. We have engineered novel virus-like-particle (VLP) technology that is able to display complex libraries of random peptide sequences on a surface-exposed loop in the coat protein without disruption of pro...
متن کاملINHIBITORY EFFECT OF STEVIA AND ROSA EXTRACTS AGAINST BACTERIAL QUORUM SENSING
Background & Aims: Quorum Sensing is a mechanism by which orchestrate the expression of many genes in bacteria. Therefore, any interference with the system will inhibit bacterial infections. The principal purpose of the research was to evaluate the potential of anti-quorum sensing of Rosa damascena and Stevia rebaudiana against Staphylococcus aureus. Materials & Methods: Ten isolates of Staphy...
متن کاملTargeting agr- and agr-Like Quorum Sensing Systems for Development of Common Therapeutics to Treat Multiple Gram-Positive Bacterial Infections
Invasive infection by the Gram-positive pathogen Staphylococcus aureus is controlled by a four gene operon, agr that encodes a quorum sensing system for the regulation of virulence. While agr has been well studied in S. aureus, the contribution of agr homologues and analogues in other Gram-positive pathogens is just beginning to be understood. Intriguingly, other significant human pathogens, in...
متن کاملTargeting Staphylococcus aureus Quorum Sensing with Nonpeptidic Small Molecule Inhibitors
A series of 3-oxo-C12-HSL, tetramic acid, and tetronic acid analogues were synthesized to gain insights into the structural requirements for quorum sensing inhibition in Staphylococcus aureus. Compounds active against agr were noncompetitive inhibitors of the autoinducing peptide (AIP) activated AgrC receptor, by altering the activation efficacy of the cognate AIP-1. They appeared to act as neg...
متن کاملQuorum Sensing in Microbial Virulence
Cell-to cell communication occurs via a signaling pathway referred to as quorum sensing. There are four main types of these systems according to the chemical nature of signal molecules used by microorganisms to elicit expression of target genes in response to environmental stimuli or need of microbial communities. Type I system acts by using acyl homoserine lactones as signals to trigger the ex...
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عنوان ژورنال:
دوره 10 شماره
صفحات -
تاریخ انتشار 2015